Alka-Seltzer Plus Cold and Cough

Aspirin, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine bitartrate · Tablet, Effervescent · Oral

Over the counter Histamine-1 Receptor Antagonist Nonsteroidal Anti-inflammatory Drug Platelet Aggregation Inhibitor

Active ingredient

Active ingredients (in each tablet) Aspirin 325 mg (NSAID)* Chlorpheniramine maleate 2 mg Dextromethorphan hydrobromide 10 mg Phenylephrine bitartrate 7.8 mg *nonsteroidal anti-inflammatory drug

Purpose

Purposes Pain reliever/fever reducer Antihistamine Cough suppressant Nasal decongestant

Uses

Uses Uses  temporarily relieves these symptoms due to a cold with cough:  ·minor aches and pains  ·headache  ·cough  ·runny nose  ·nasal and sinus congestion  ·sneezing  ·sore throat  ·temporarily reduces fever

Warnings

Warnings Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include:  hives  facial swelling  asthma (wheezing)  shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ● are age 60 or older ● have had stomach ulcers or bleeding problems ● take a blood thinning (anticoagulant) or steroid drug ● take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ● have 3 or more alcoholic drinks every day while using this product ● take more or for a longer time than directed Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use to sedate children.

Do not use

Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. ● if you have ever had an allergic reaction to this product or any of its ingredients ● in children under 12 years of age

Ask a doctor before use

Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have: ● asthma ● diabetes ● thyroid disease ● glaucoma ● cough with excessive phlegm (mucus) ● a breathing problem such as emphysema or chronic bronchitis ● difficulty in urination due to enlargement of the prostate gland ● persistent or chronic cough such as occurs with smoking, asthma, or emphysema ● a sodium-restricted diet

When using this product

When using this product ● do not exceed recommended dosage  may cause marked drowsiness ● avoid alcoholic drinks ● excitability may occur, especially in children ● alcohol, sedatives, and tranquilizers may increase drowsiness ● be careful when driving a motor vehicle or operating machinery

Stop use and ask a doctor

Stop use and ask a doctor if Stop use and ask a doctor if ● an allergic reaction occurs. Seek medical help right away. ● you experience any of the following signs of stomach bleeding ● feel faint ● vomit blood ● have bloody or black stools ● have stomach pain that does not get better  pain, cough, or nasal congestion gets worse or lasts more than 7 days  fever gets worse or lasts more than 3 days  redness or swelling is present  new symptoms occur  ringing in the ears or a loss of hearing occurs  cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.  nervousness, dizziness, or sleeplessness occurs

Pregnancy or breast-feeding

If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

Directions Directions ● adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor. ● children under 12 years: do not use

Inactive ingredients

Inactive ingredients acesulfame potassium, anhydrous citric acid, aspartame, calcium silicate, dimethicone, docusate sodium, FD&C red #40, flavors, mannitol, povidone, sodium benzoate, sodium bicarbonate

Questions?

Questions or comments? Questions or comments? 1-800-986-0369 (Mon - Fri 9AM - 5PM EST)

Label text from the FDA structured product label by Bayer HealthCare LLC. (revised Dec 4, 2025). Long sections are shortened; the complete label is on DailyMed.

Active ingredients

Aspirin in 1 product
Chlorpheniramine Maleate in 1 product
Dextromethorphan Hydrobromide in 1 product
Phenylephrine Bitartrate in 1 product

Alka-Seltzer Plus Cold and Cough NDC products (1)

NDC	Strength & form	Labeler	Type
0280-1555	Aspirin 325 mg/1; Chlorpheniramine Maleate 2 mg/1; Dextromethorphan Hydrobromide 10 mg/1; Phenylephrine Bitartrate 7.8… Tablet, Effervescent	Bayer HealthCare LLC.	OTC MONOGRAPH DRUG

Frequently asked questions

What is Alka-Seltzer Plus Cold and Cough used for?

Who makes Alka-Seltzer Plus Cold and Cough?

Alka-Seltzer Plus Cold and Cough is listed by 1 labeler in the FDA NDC directory, including Bayer HealthCare LLC..