Alka-Seltzer Plus Cold Medicine Sparkling Original

ASPIRIN, CHLORPHENIRAMINE MALEATE, and PHENYLEPHRINE BITARTRATE · Tablet, Effervescent · Oral

Over the counter Histamine-1 Receptor Antagonist Nonsteroidal Anti-inflammatory Drug Platelet Aggregation Inhibitor

Active ingredient

Active ingredients (in each tablet) Purposes Aspirin 325 mg (NSAID) nonsteroidal anti-inflammatory drug Pain reliever/fever reducer Chlorpheniramine maleate 2 mg Antihistamine Phenylephrine bitartrate 7.8 mg Nasal decongestant

Purpose

Uses

Uses temporarily relieves these symptoms due to a cold: temporarily reduces fever

Warnings

Warnings Reye's syndrome Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert Aspirin may cause a severe allergic reaction which may include: hives facial swelling asthma (wheezing) shock Stomach bleeding warning This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Sore throat warning If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use to sedate children. Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients in children under 12 years of age Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma diabetes thyroid disease glaucoma difficulty in urination due to enlargement of the prostate gland a breathing problem such as emphysema or chronic bronchitis a sodium-restricted diet Ask a doctor or pharmacist before use if you are taking a prescription drug for gout diabetes arthritis taking sedatives or tranquilizers When using this product do not exceed recommended dosage excitability may occur, especially in children you may get drowsy avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs nervousness, dizziness, or sleeplessness occurs If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Do not use

Do not use to sedate children. Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients in children under 12 years of age

Ask a doctor before use

Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma diabetes thyroid disease glaucoma difficulty in urination due to enlargement of the prostate gland a breathing problem such as emphysema or chronic bronchitis a sodium-restricted diet

Ask a doctor or pharmacist

Ask a doctor or pharmacist before use if you are taking a prescription drug for gout diabetes arthritis taking sedatives or tranquilizers

When using this product

When using this product do not exceed recommended dosage excitability may occur, especially in children you may get drowsy avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery

Stop use and ask a doctor

Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs nervousness, dizziness, or sleeplessness occurs

Pregnancy or breast-feeding

If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

Directions adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor. children under 12 years: do not use

Other information

Other information each tablet contains: sodium 474 mg Phenylketonurics: Contains Phenylalanine 8.4 mg Per Tablet store at room temperature. Avoid excessive heat.

Inactive ingredients

Inactive ingredients acesulfame potassium, anhydrous citric acid, aspartame, calcium silicate, dimethylpolysiloxane, docusate sodium, flavors, mannitol, povidone, sodium benzoate, sodium bicarbonate

Questions?

Questions or comments? 1-800-986-0369 (Mon-Fri 9AM – 5PM EST)

Label text from the FDA structured product label by Bayer HealthCare LLC. (revised Dec 4, 2025). Long sections are shortened; the complete label is on DailyMed.

Active ingredients

Aspirin in 1 product
Chlorpheniramine Maleate in 1 product
Phenylephrine Bitartrate in 1 product

Alka-Seltzer Plus Cold Medicine Sparkling Original NDC products (1)

NDC	Strength & form	Labeler	Type
0280-1400	Aspirin 325 mg/1; Chlorpheniramine Maleate 2 mg/1; Phenylephrine Bitartrate 7.8 mg/1 Tablet, Effervescent	Bayer HealthCare LLC.	OTC MONOGRAPH DRUG

Frequently asked questions

What is Alka-Seltzer Plus Cold Medicine Sparkling Original used for?

Uses temporarily relieves these symptoms due to a cold: temporarily reduces fever

Who makes Alka-Seltzer Plus Cold Medicine Sparkling Original?

Alka-Seltzer Plus Cold Medicine Sparkling Original is listed by 1 labeler in the FDA NDC directory, including Bayer HealthCare LLC..