Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz
chlorpheniramine maleate, dextromethorphan hydrobromide, acetaminophen, phenylephrine hydrochloride · Tablet, Effervescent · Oral
Active ingredient
Active ingredients (in each tablet) Purposes Acetaminophen 325 mg…………….………...Pain reliever/fever reducer Chlorpheniramine maleate 2 mg……………………..……..Antihistamine Dextromethorphan hydrobromide 10 mg……………Cough suppressant Phenylephrine hydrochloride 5 mg………………….Nasal decongestant
Uses
Uses temporarily relieves these symptoms due to a cold or flu: minor aches and pains headache cough sore throat runny nose sneezing nasal congestion · sinus temporarily reduces fever
Warnings
Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take · more than 4,000 mg of acetaminophen in 24 hours · with other drugs containing acetaminophen · 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin or severe allergic reactions. Symptoms may include: · skin reddening · blisters · rash · hives · facial swelling · asthma (wheezing) · shock If a skin or general allergic reaction occurs, stop use and seek medical help right away. Sore throat warning : If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use to sedate children. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product if you have ever had an allergic reaction to this product or any of its ingredients in children under 12 years of age Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product do not exceed recommended dosage may cause marked drowsiness avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children Stop use and ask a doctor if pain, cough, or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. nervousness, dizziness, or sleeplessness occurs If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Do not use
Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product if you have ever had an allergic reaction to this product or any of its ingredients in children under 12 years of age
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers
When using this product
When using this product do not exceed recommended dosage may cause marked drowsiness avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children
Stop use and ask a doctor
Stop use and ask a doctor if pain, cough, or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. nervousness, dizziness, or sleeplessness occurs
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
Directions do not take more than the recommended dose adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 10 tablets in 24 hours or as directed by a doctor. children under 12 years: do not use
Inactive ingredients
Inactive ingredients anhydrous citric acid, calcium silicate, dimethicone, flavors, magnesium stearate, maltodextrin, mannitol, potassium bicarbonate, povidone, sodium bicarbonate, sucralose
Questions?
Questions or comments? 1-800-986-0369 (Mon-Fri 9AM - 5PM EST)
Label text from the FDA structured product label by Bayer HealthCare LLC. (revised Dec 4, 2025). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Chlorpheniramine Maleate in 1 product
- Phenylephrine Hydrochloride in 1 product
- Dextromethorphan Hydrobromide in 1 product
- Acetaminophen in 1 product
Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz NDC products (1)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 0280-0055 | Chlorpheniramine Maleate 2 mg/1; Phenylephrine Hydrochloride 5 mg/1; Dextromethorphan Hydrobromide 10 mg/1;… Tablet, Effervescent | Bayer HealthCare LLC. | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz used for?
Uses temporarily relieves these symptoms due to a cold or flu: minor aches and pains headache cough sore throat runny nose sneezing nasal congestion · sinus temporarily reduces fever
Who makes Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz?
Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz is listed by 1 labeler in the FDA NDC directory, including Bayer HealthCare LLC..