Benadryl Extra Strength Itch Cooling
Diphenhydramine Hydrochloride and Zinc Acetate · Spray · Topical
Active ingredient
Active ingredients Purpose Diphenhydramine HCl 2% Topical analgesic Zinc acetate 0.1% Skin protectant
Purpose
Active ingredients Purpose Diphenhydramine HCl 2% Topical analgesic Zinc acetate 0.1% Skin protectant
Uses
Uses temporarily relieves pain and itching associated with: insect bites minor burns sunburn minor skin irritations minor cuts scrapes rashes due to poison ivy, poison oak, and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac
Warnings
Warnings For external use only. Flammable. Keep away from fire or flame. Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox on measles When using this product avoid contact with eyes Stop use and ask a doctor if condition worsens or does not improve within 7 days symptoms persist for more than 7 days or clear up and occur again within a few days Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Do not use
Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth
Ask a doctor before use
Ask a doctor before use on chicken pox on measles
When using this product
When using this product avoid contact with eyes
Stop use and ask a doctor
Stop use and ask a doctor if condition worsens or does not improve within 7 days symptoms persist for more than 7 days or clear up and occur again within a few days
Keep out of reach of children
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Directions
Directions do not use more than directed adults and children 2 years of age and older: spray on affected area not more than 3 to 4 times daily children under 2 years of age: ask a doctor
Other information
Other information store at 20° to 25° C (68° to 77° F)
Inactive ingredients
Inactive ingredients alcohol, glycerin, PVP, purified water, tromethamine
Questions?
Questions? call 1-800-524-2624 (English/Spanish)
Label text from the FDA structured product label by Kenvue Brands LLC (revised Jul 18, 2025). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Diphenhydramine Hydrochloride in 1 product
- Zinc Acetate in 1 product
Benadryl Extra Strength Itch Cooling NDC products (1)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 69968-0270 | Diphenhydramine Hydrochloride 20 mg/mL; Zinc Acetate 1 mg/mL Spray | Kenvue Brands LLC | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Benadryl Extra Strength Itch Cooling used for?
Uses temporarily relieves pain and itching associated with: insect bites minor burns sunburn minor skin irritations minor cuts scrapes rashes due to poison ivy, poison oak, and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac
Who makes Benadryl Extra Strength Itch Cooling?
Benadryl Extra Strength Itch Cooling is listed by 1 labeler in the FDA NDC directory, including Kenvue Brands LLC.