CVS Maximum Strength Cold and Flu Relief
Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin ,Phenylephrine HCL · Liquid · Oral
Active ingredient
Active ingredients (in each 20 mL) Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Guaifenesin 400 mg Expectorant Phenylephrine HCl 10 mg Nasal decongestant
Purpose
Active ingredients (in each 20 mL) Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Guaifenesin 400 mg Expectorant Phenylephrine HCl 10 mg Nasal decongestant
Uses
Uses ▪ temporarily relieves these common cold and flu symptoms: ▪ cough ▪ nasal congestion ▪ minor aches and pains ▪ sore throat ▪ sinus congestion and pressure ▪ headache ▪ temporarily reduces fever ▪ temporarily promotes nasal and/or sinus drainage ▪ helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive
Warnings
Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: ▪ more than 6 doses in 24 hours, which is the maximum daily amount ▪ with other drugs containing acetaminophen ▪ 3 or more alcoholic drinks daily while using this product Generic Section Allergy alert : Acetaminophen may cause severe skin reactions. Symptoms may include: ▪ skin ▪ blisters ▪ rash. If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning: if sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. ▪ for children under 12 years of age ▪ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have ▪ liver disease ▪ heart disease ▪ high blood pressure ▪ thyroid disease ▪ diabetes ▪ trouble urinating due to an enlarged prostate gland ▪ persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema ▪ cough that occurs with too much phlegm (mucus) Ask a doctor or pharmacist before use if ▪ you are taking the blood thinning drug warfarin When using this product do not use more than directed Stop use and ask a doctor if ▪ nervousness, dizziness, or sleeplessness occur ▪ pain, nasal congestion, or cough gets worse, or lasts more than 7 days ▪ fever gets worse, or lasts more than 3 days ▪ redness or swelling is present ▪ new symptoms occur ▪ cough comes back, or occurs with rash, or persistent headache. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.
Do not use
Do not use ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. ▪ for children under 12 years of age ▪ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use
Ask a doctor before use if you have ▪ liver disease ▪ heart disease ▪ high blood pressure ▪ thyroid disease ▪ diabetes ▪ trouble urinating due to an enlarged prostate gland ▪ persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema ▪ cough that occurs with too much phlegm (mucus)
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if ▪ you are taking the blood thinning drug warfarin
When using this product
When using this product do not use more than directed
Stop use and ask a doctor
Stop use and ask a doctor if ▪ nervousness, dizziness, or sleeplessness occur ▪ pain, nasal congestion, or cough gets worse, or lasts more than 7 days ▪ fever gets worse, or lasts more than 3 days ▪ redness or swelling is present ▪ new symptoms occur ▪ cough comes back, or occurs with rash, or persistent headache. These could be signs of a serious condition.
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children.
Directions
Directions ▪ do not take more than directed (see Overdose Warning) ) ▪ do not take more than 6 doses in any 24-hour period ▪ measure only with dosing cup provided ▪ do not use dosing cup with other products ▪ dose as follows or as directed by a doctor ▪ adults and children 12 years of age and older: 20 mL in dosing cup provided every 4 hours ▪ children under 12 years of age: Do not use
Other information
Other information ▪ each 20 mL contains: sodium 8 mg ▪ store at room temperature ▪ do not refrigerate
Inactive ingredients
Inactive ingredients anhydrous citric acid, edetate disodium, FD&C blue #1, FD&C red #40, flavors, potassium citrate, propylene glycol, propyl gallate, purified water, sodium benzoate, sorbitol, sucralose, xanthan gum
Questions?
Questions or comments? 1-866-467-2748
Label text from the FDA structured product label by CVS PHARMACY (revised Aug 19, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 2 products
- Dextromethorphan Hydrobromide in 2 products
- Guaifenesin in 2 products
- Phenylephrine Hydrochloride in 2 products
CVS Maximum Strength Cold and Flu Relief NDC products (2)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 69842-903 | Acetaminophen 650 mg/20mL; Dextromethorphan Hydrobromide 20 mg/20mL; Guaifenesin 400 mg/20mL; Phenylephrine… Liquid | CVS PHARMACY | OTC MONOGRAPH DRUG |
| 69842-566 | Acetaminophen 650 mg/20mL; Dextromethorphan Hydrobromide 20 mg/20mL; Guaifenesin 400 mg/20mL; Phenylephrine… Liquid | CVS PHARMACY, INC | OTC MONOGRAPH DRUG |
Frequently asked questions
What is CVS Maximum Strength Cold and Flu Relief used for?
Uses ▪ temporarily relieves these common cold and flu symptoms: ▪ cough ▪ nasal congestion ▪ minor aches and pains ▪ sore throat ▪ sinus congestion and pressure ▪ headache ▪ temporarily reduces fever ▪ temporarily promotes nasal and/or sinus drainage ▪ helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive
Who makes CVS Maximum Strength Cold and Flu Relief?
CVS Maximum Strength Cold and Flu Relief is listed by 2 labelers in the FDA NDC directory, including CVS PHARMACY, CVS PHARMACY, INC.