CVS Nighttime
Diphenhydramine Hydrochloride and Acetaminophen · Liquid · Oral
Active ingredient
Active ingredients (in each 30 mL) Acetaminophen 1000 mg Diphenhydramine HCl 50 mg
Purpose
Purpose Pain reliever Nighttime sleep-aid
Uses
Uses ▪ for the temporary relief of occasional minor aches and pains with accompanying sleeplessness.
Warnings
Warnings Liver warning : This product contains acetaminophen. Severe liver damage may occur if ▪ adult takes more than 4 doses (30 mL each) in 24 hrs., which is the maximum daily amount for this product ▪ taken with other drugs containing acetaminophen ▪ 3 or more alcoholic drinks every day while using this product Allergy Alert : Acetaminophen may cause severe skin reactions. Symptoms may include: ▪ skin reddening ▪ blisters ▪ rash If a skin reaction occurs, stop use and seek medical help right away Do not use ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. ▪ for children under 12 years of age ▪ with any other product containing diphenhydramine, even one used on skin. Ask a doctor before use if you have
• liver disease
• a breathing problem such as emphysema or chronic bronchitis
• glaucoma
• difficulty in urination due to enlargement of the prostate gland Ask a doctor or pharmacist before use if you are
• taking the blood thinning drug warfarin
• taking sedatives or tranquilizers When using this product
• avoid alcoholic beverages
• drowsiness will occur
• do not drive a motor vehicle or operate machinery Stop use and ask a doctor if
• pain gets worse or lasts more than 10 days
• fever gets worse or lasts more than 3 days
• new symptoms occur
• Sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness. These could be signs of a serious condition. If pregnant or breast-feeding , ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Do not use
Do not use ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. ▪ for children under 12 years of age ▪ with any other product containing diphenhydramine, even one used on skin.
Ask a doctor before use
Ask a doctor before use if you have
• liver disease
• a breathing problem such as emphysema or chronic bronchitis
• glaucoma
• difficulty in urination due to enlargement of the prostate gland
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are
• taking the blood thinning drug warfarin
• taking sedatives or tranquilizers
When using this product
When using this product
• avoid alcoholic beverages
• drowsiness will occur
• do not drive a motor vehicle or operate machinery
Stop use and ask a doctor
Stop use and ask a doctor if
• pain gets worse or lasts more than 10 days
• fever gets worse or lasts more than 3 days
• new symptoms occur
• Sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness. These could be signs of a serious condition.
Pregnancy or breast-feeding
If pregnant or breast-feeding , ask a health professional before use.
Keep out of reach of children
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
Directions ▪ take only one dose (30 mL) per day (24 hours) ▪ Only use dose cup provided adults & children 12 yrs & over 30 mL at bedtime children under 12 yrs do not use
Other information
Other information ▪ each 30 mL contains: sodium 10 mg ▪ store at room temperature ▪ very low sodium
Inactive ingredients
Inactive ingredients citric acid, flavors, FD&C Blue No. 1, FD&C Red No. 40, glycerin, potassium citrate, propylene glycol, purified water, sodium benzoate, sorbitol, sucralose.
Questions?
Questions or comments? 1-866-467-2748
Label text from the FDA structured product label by CVS PHARMACY (revised Aug 14, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 1 product
- Diphenhydramine Hydrochloride in 1 product
CVS Nighttime NDC products (1)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 69842-448 | Acetaminophen 1000 mg/30mL; Diphenhydramine Hydrochloride 50 mg/30mL Liquid | CVS PHARMACY | OTC MONOGRAPH DRUG |
Frequently asked questions
What is CVS Nighttime used for?
Uses ▪ for the temporary relief of occasional minor aches and pains with accompanying sleeplessness.
Who makes CVS Nighttime?
CVS Nighttime is listed by 1 labeler in the FDA NDC directory, including CVS PHARMACY.