CVS Severe Multi-Symptom Cough Cold Flu
Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride · Liquid · Oral
Active ingredient
Active ingredients (in each 20 ml) Acetaminophen, USP 650 mg Dextromethorphan HBr, USP 20 mg Guaifenesin, USP 400 mg Phenylephrine HCl, USP 10 mg
Purpose
Purposes Pain reliever/Fever reducer Cough suppressant Expectorant Nasal decongestant
Uses
Uses ▪ temporarily relieves these symptoms occurring with a cold or flu: ▪ cough due to minor throat and bronchial irritation ▪ nasal congestion ▪ sinus congestion and pressure ▪ minor aches and pains ▪ sore throat ▪ headache ▪ temporarily reduces fever ▪ helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive
Warnings
Warnings Liver warning This product contains acetaminophen. Severe liver damage may occur if you take ▪ more than 6 doses in any 24-hour period, which is the maximum daily amount ▪ with other drugs containing acetaminophen ▪ 3 or more alcoholic drinks every day while using this product Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include: ▪ skin reddening ▪ blisters ▪ rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use ▪ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. Ask a doctor before use if you have ▪ liver disease ▪ heart disease ▪ high blood pressure ▪ thyroid disease ▪ diabetes ▪ trouble urinating due to an enlarged prostate gland ▪ cough that occurs with too much phlegm (mucus) ▪ a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema Ask a doctor or pharmacist before use if you are ▪ taking the blood thinning drug warfarin ▪ taking any other oral nasal decongestant or stimulant ▪ taking any other pain reliever/fever reducer When using this product do not use more than directed Stop use and ask a doctor if ▪ you get nervous, dizzy, or sleepless ▪ pain, cough, or nasal congestion gets worse or lasts more than 7 days ▪ fever gets worse or lasts more than 3 days ▪ redness or swelling is present ▪ new symptoms occur ▪ cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222. Prompt medical attention is critical for adults as well as for children, even if you do not notice any signs or symptoms.
Do not use
Do not use ▪ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
Ask a doctor before use
Ask a doctor before use if you have ▪ liver disease ▪ heart disease ▪ high blood pressure ▪ thyroid disease ▪ diabetes ▪ trouble urinating due to an enlarged prostate gland ▪ cough that occurs with too much phlegm (mucus) ▪ a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are ▪ taking the blood thinning drug warfarin ▪ taking any other oral nasal decongestant or stimulant ▪ taking any other pain reliever/fever reducer
When using this product
When using this product do not use more than directed
Stop use and ask a doctor
Stop use and ask a doctor if ▪ you get nervous, dizzy, or sleepless ▪ pain, cough, or nasal congestion gets worse or lasts more than 7 days ▪ fever gets worse or lasts more than 3 days ▪ redness or swelling is present ▪ new symptoms occur ▪ cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222. Prompt medical attention is critical for adults as well as for children, even if you do not notice any signs or symptoms.
Directions
Directions ▪ do not take more than 6 doses in any 24-hour period ▪ do not exceed recommended dosage. Taking more than the recommended dose (overdose) may cause serious liver damage. ▪ measure only with dosing cup provided ▪ keep dosing cup with product ▪ ml = milliliter ▪ this adult product is not intended for use in children under 12 years of age age dose adults and children 12 years and over 20 ml every 4 hours children under 12 years do not use
Other information
Other information
• each 20 ml contains: sodium 7 mg
• store at room temperature. Do not refrigerate.
Inactive ingredients
Inactive ingredients anhydrous citric acid, edetate disodium, FD&C red no. 40, glycerin, flavors, potassium citrate, propylene glycol, propyl gallate, purified water, sodium benzoate, sorbitol solution, sucralose, xanthan gum
Questions?
Questions or comments? 1-866-467-2748
Label text from the FDA structured product label by CVS PHARMACY (revised Aug 14, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 1 product
- Dextromethorphan Hydrobromide in 1 product
- Guaifenesin in 1 product
- Phenylephrine Hydrochloride in 1 product
CVS Severe Multi-Symptom Cough Cold Flu NDC products (1)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 51316-630 | Acetaminophen 650 mg/20mL; Dextromethorphan Hydrobromide 20 mg/20mL; Guaifenesin 400 mg/20mL; Phenylephrine… Liquid | CVS PHARMACY | OTC MONOGRAPH DRUG |
Frequently asked questions
What is CVS Severe Multi-Symptom Cough Cold Flu used for?
Uses ▪ temporarily relieves these symptoms occurring with a cold or flu: ▪ cough due to minor throat and bronchial irritation ▪ nasal congestion ▪ sinus congestion and pressure ▪ minor aches and pains ▪ sore throat ▪ headache ▪ temporarily reduces fever ▪ helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive
Who makes CVS Severe Multi-Symptom Cough Cold Flu?
CVS Severe Multi-Symptom Cough Cold Flu is listed by 1 labeler in the FDA NDC directory, including CVS PHARMACY.