Daytime Nighttime

Daytime - Acetaminophen, Dextromethorphan HBr, Phenylephrine HCL and Nighttime - Acetaminophen, Dextromethorphan HBr, Doxylamine succinate · Kit · Oral

Over the counter

Active ingredient

Daytime Active ingredients (in each caplet) Acetaminophen 325 mg Guaifenesin 200 mg Nighttime Active ingredients (in each caplet) Acetaminophen 325 mg Dextromethorphan HBr 10 mg Triprolidine HCl 1.25 mg

Purpose

Daytime Pain reliever/fever reducer Expectorant Nighttime Pain reliever/fever reducer Cough suppressant Antihistamine

Uses

Daytime temporarily relieves these common cold and flu symptoms: minor aches and pains headache sore throat helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive temporarily reduces fever Nighttime temporarily relieves these common cold and flu symptoms: cough minor aches and pains sore throat headache runny nose sneezing itching of the nose or throat itchy, watery eyes due to hay fever temporarily reduces fever controls cough to help you get to sleep

Warnings

Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: more than 12 caplets in 24 hours, which is the maximum daily amount for this product with other drugs containing acetaminophen 3 or more alcoholic drinks daily while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use Daytime with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. Nighttime with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have Daytime liver disease persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema cough that occurs with too much phlegm (mucus) Nighttime liver disease glaucoma trouble urinating due to an enlarged prostate gland a breathing problem such as emphysema or chronic bronchitis persistent or chronic cough such as occurs with smoking, asthma, or emphysema cough that occurs with too much phlegm (mucus) Ask a doctor or pharmacist before use Daytime if you are taking the blood thinning drug warfarin Nighttime taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product Daytime do not use more than directed Nighttime do not use more than directed excitability may occur, especially in children marked drowsiness may occur alcohol, sedatives, and tranquilizers may increase drowsiness avoid alcoholic drinks use caution when driving a motor vehicle or operating machinery Stop use and ask a doctor if Daytime pain or cough gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition. new symptoms occur Nighttime pain or cough gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back, or occurs with rash or headache that lasts. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Overdose warning: Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Do not use

Do not use Daytime with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. Nighttime with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

Ask a doctor before use

Ask a doctor before use if you have Daytime liver disease persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema cough that occurs with too much phlegm (mucus) Nighttime liver disease glaucoma trouble urinating due to an enlarged prostate gland a breathing problem such as emphysema or chronic bronchitis persistent or chronic cough such as occurs with smoking, asthma, or emphysema cough that occurs with too much phlegm (mucus)

Ask a doctor or pharmacist

Ask a doctor or pharmacist before use Daytime if you are taking the blood thinning drug warfarin Nighttime taking the blood thinning drug warfarin taking sedatives or tranquilizers

When using this product

When using this product Daytime do not use more than directed Nighttime do not use more than directed excitability may occur, especially in children marked drowsiness may occur alcohol, sedatives, and tranquilizers may increase drowsiness avoid alcoholic drinks use caution when driving a motor vehicle or operating machinery

Stop use and ask a doctor

Stop use and ask a doctor if Daytime pain or cough gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition. new symptoms occur Nighttime pain or cough gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back, or occurs with rash or headache that lasts. These could be signs of a serious condition.

Pregnancy or breast-feeding

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children

Keep out of reach of children. Overdose warning: Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Directions

Directions Daytime do not take more than directed (see Overdose warning) do not take more than 12 caplets in any 24-hour period adults and children 12 years of age and over: take 2 caplets every 4 hours children under 12 years of age: do not use Nighttime do not take more than directed (see Overdose warning) do not take more than 8 caplets in any 24-hour period adults and children 12 years of age and over: take 2 caplets every 4 hours children under 12 years of age: do not use

Other information

Other information each caplet contains: sodium 3 mg store at 20-25°C (68-77°F), excursion permitted between 15-30°C (59-86°F)

Inactive ingredients

Inactive ingredients Daytime colloidal silicon dioxide, croscarmellose sodium, crospovidone, FD&C red no. 40, FD&C yellow no. 6, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, talc, titanium dioxide Inactive ingredients Nighttime colloidal silicon dioxide, croscarmellose sodium, hypromellose, mica, microcrystalline cellulose, povidone, stearic acid, talc, titanium dioxide, triacetin

Questions?

Questions or comments? Call 1-800-632-6900

Label text from the FDA structured product label by KROGER COMPANY (revised Aug 16, 2026). Long sections are shortened; the complete label is on DailyMed.

Daytime Nighttime NDC products (10)

NDC	Strength & form	Labeler	Type
51316-875	Kit	CVS HEALTH CORP	OTC MONOGRAPH DRUG
37808-191	Kit	H-E-B	OTC MONOGRAPH DRUG
41226-790	Kit	Kroger	OTC MONOGRAPH DRUG
41226-678	Kit	KROGER COMPANY	OTC MONOGRAPH DRUG
41226-778	Kit	KROGER COMPANY	OTC MONOGRAPH DRUG
11673-474	Kit	TARGET CORPORATION	OTC MONOGRAPH DRUG
11673-591	Kit	TARGET CORPORATION	OTC MONOGRAPH DRUG
11673-757	Kit	TARGET CORPORATION	OTC MONOGRAPH DRUG
11673-848	Kit	TARGET CORPORATION	OTC MONOGRAPH DRUG
0363-1911	Kit	WALGREENS	OTC MONOGRAPH DRUG

Frequently asked questions

What is Daytime Nighttime used for?

Who makes Daytime Nighttime?

Daytime Nighttime is listed by 6 labelers in the FDA NDC directory, including CVS HEALTH CORP, H-E-B, Kroger, KROGER COMPANY.