daytime severe cold and flu
acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride · Solution · Oral
Active ingredient
Active ingredients (in each 15 mL) Acetaminophen 325 mg Dextromethorphan HBr 10 mg Guaifenesin 200 mg Phenylephrine HCl 5 mg
Purpose
Purpose Pain reliever/fever reducer Cough suppressant Expectorant Nasal decongestant
Uses
Uses
• temporarily relieves common cold/flu symptoms:
• sinus congestion and pressure
• nasal congestion
• minor aches and pains
• headache
• reduces swelling of nasal passages
• sore throat
• promotes nasal and/or sinus drainage
• fever
• cough due to minor throat and bronchial irritation
• temporarily restores freer breathing through the nose
• helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive
Warnings
Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if
• adult takes more than 4,000 mg of acetaminophen in 24 hours
• child takes more than 5 doses in 24 hours
• taken with other drugs containing acetaminophen
• adult has 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
• skin reddening
• blisters
• rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use
• with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
• if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
• if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have
• liver disease
• heart disease
• high blood pressure
• thyroid disease
• diabetes
• trouble urinating due to an enlarged prostate gland
• cough that occurs with too much phlegm (mucus)
• persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin When using this product do not use more than directed Stop use and ask a doctor if
• you get nervous, dizzy or sleepless
• fever gets worse or lasts more than 3 days
• redness or swelling is present
• new symptoms occur
• pain, nasal congestion, or cough gets worse or lasts more than 5 days (children) or 7 days (adults)
• cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Do not use
Do not use
• with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
• if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
• if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use
Ask a doctor before use if you have
• liver disease
• heart disease
• high blood pressure
• thyroid disease
• diabetes
• trouble urinating due to an enlarged prostate gland
• cough that occurs with too much phlegm (mucus)
• persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin
When using this product
When using this product do not use more than directed
Stop use and ask a doctor
Stop use and ask a doctor if
• you get nervous, dizzy or sleepless
• fever gets worse or lasts more than 3 days
• redness or swelling is present
• new symptoms occur
• pain, nasal congestion, or cough gets worse or lasts more than 5 days (children) or 7 days (adults)
• cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children. Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
Directions
• take only as directed – see Overdose warning
• only use the dose cup provided
• do not exceed 4 doses per 24 hrs adults & children 12 yrs & over 30 mL every 4 hrs children 6 to under 12 yrs 15 mL every 4 hrs children 4 to under 6 yrs ask a doctor children under 4 yrs do not use
Other information
Other information
• each 15 mL contains: sodium 15 mg
• store at 20-25 ° C (68-77 ° F). Do not refrigerate.
Inactive ingredients
Inactive ingredients anhydrous citric acid, FD&C yellow #6, flavor, glycerin, menthol, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sodium benzoate, sodium chloride, sodium citrate, sorbitol solution, sucralose, xanthan gum
Questions?
Questions or comments? 1-800-719-9260
Label text from the FDA structured product label by Amazon.com Services LLC (revised Jun 16, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 15 products
- Dextromethorphan Hydrobromide in 15 products
- Guaifenesin in 14 products
- Phenylephrine Hydrochloride in 14 products
daytime severe cold and flu NDC products (15)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 72288-557 | Acetaminophen 325 mg/15mL; Dextromethorphan Hydrobromide 10 mg/15mL; Guaifenesin 200 mg/15mL; Phenylephrine… Solution | Amazon.com Services LLC | OTC MONOGRAPH DRUG |
| 72288-655 | Acetaminophen 325 mg/15mL; Dextromethorphan Hydrobromide 10 mg/15mL; Guaifenesin 200 mg/15mL; Phenylephrine… Solution | Amazon.com Services LLC | OTC MONOGRAPH DRUG |
| 51316-525 | Dextromethorphan Hydrobromide 10 mg/1; Phenylephrine Hydrochloride 5 mg/1; Guaifenesin 200 mg/1; Acetaminophen 325 mg/1 Capsule | CVS HEALTH CORP | OTC MONOGRAPH DRUG |
| 51316-681 | Acetaminophen 325 mg/15mL; Dextromethorphan Hydrobromide 10 mg/15mL; Guaifenesin 200 mg/15mL; Phenylephrine… Solution | CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED | OTC MONOGRAPH DRUG |
| 51316-731 | Acetaminophen 325 mg/1; Dextromethorphan Hydrobromide 10 mg/1; Guaifenesin 200 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Film Coated | CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED | OTC MONOGRAPH DRUG |
| 53943-178 | Acetaminophen 325 mg/1; Dextromethorphan Hydrobromide 10 mg/1; Guaifenesin 200 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | DISCOUNT DRUG MART | OTC MONOGRAPH DRUG |
| 69676-0093 | Dextromethorphan Hydrobromide 20 mg/20mL; Acetaminophen 650 mg/20mL Suspension | Genexa Inc. | OTC MONOGRAPH DRUG |
| 85828-774 | Phenylephrine Hydrochloride 5 mg/15mL; Acetaminophen 325 mg/15mL; Guaifenesin 200 mg/15mL; Dextromethorphan… Liquid | Grocery Outlet, Inc. | OTC MONOGRAPH DRUG |
| 37808-603 | Acetaminophen 325 mg/15mL; Dextromethorphan Hydrobromide 10 mg/15mL; Guaifenesin 200 mg/15mL; Phenylephrine… Solution | H E B | OTC MONOGRAPH DRUG |
| 37808-178 | Acetaminophen 325 mg/1; Dextromethorphan Hydrobromide 10 mg/1; Guaifenesin 200 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | HEB | OTC MONOGRAPH DRUG |
| 53345-021 | Acetaminophen 325 mg/1; Dextromethorphan Hydrobromide 10 mg/1; Guaifenesin 200 mg/1; Phenylephrine Hydrochloride 5 mg/1 Capsule, Liquid Filled | Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. | OTC MONOGRAPH DRUG |
| 41226-774 | Phenylephrine Hydrochloride 5 mg/15mL; Acetaminophen 325 mg/15mL; Guaifenesin 200 mg/15mL; Dextromethorphan… Liquid | Kroger | OTC MONOGRAPH DRUG |
| 30142-603 | Acetaminophen 325 mg/15mL; Dextromethorphan Hydrobromide 10 mg/15mL; Guaifenesin 200 mg/15mL; Phenylephrine… Solution | Kroger Company | OTC MONOGRAPH DRUG |
| 41226-625 | Phenylephrine Hydrochloride 5 mg/1; Guaifenesin 200 mg/1; Acetaminophen 325 mg/1; Dextromethorphan Hydrobromide 10 mg/1 Capsule, Liquid Filled | KROGER COMPANY | OTC MONOGRAPH DRUG |
| 0363-5001 | Acetaminophen 325 mg/15mL; Dextromethorphan Hydrobromide 10 mg/15mL; Guaifenesin 200 mg/15mL; Phenylephrine… Solution | Walgreen Company | OTC MONOGRAPH DRUG |
Frequently asked questions
What is daytime severe cold and flu used for?
Uses • temporarily relieves common cold/flu symptoms: • sinus congestion and pressure • nasal congestion • minor aches and pains • headache • reduces swelling of nasal passages • sore throat • promotes nasal and/or sinus drainage • fever • cough due to minor throat and bronchial irritation • temporarily restores freer breathing through the nose • helps loosen phlegm (mucus) and thin bronchial…
Who makes daytime severe cold and flu?
daytime severe cold and flu is listed by 13 labelers in the FDA NDC directory, including Amazon.com Services LLC, CVS HEALTH CORP, CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED, DISCOUNT DRUG MART.