Effervescent Orange Cold Relief
Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate · Tablet, Effervescent · Oral
Active ingredient
Active ingredients (in each effervescent tablet) Aspirin 325 mg (NSAID)* Chlorpheniramine maleate 2 mg Phenylephrine Bitartrate 7.8 mg *Nonsteroidal anti-inflammatory drug
Purpose
Purpose Aspirin 325 mg (NSAID)*. . . . . . . . . . . . . . . . . . .Pain reliever/fever reducer Chlorpheniramine maleate 2 mg . . . . . . . . . . . . .Antihistamine Phenylephrine Bitartrate 7.8 mg . . . . . . . . . . . . .Nasal decongestant *Nonsteroidal anti-inflammatory drug
Uses
Uses ■ temporarily relieves these symptoms due to the common cold: ■ sneezing ■ nasal congestion ■ sore throat ■ headache ■ minor aches and pains ■ runny nose ■ sinus congestion and pressure ■ temporarily reduces fever
Warnings
Warnings Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
Do not use Do not use ■ if you have ever had an allergic reaction to any other pain reliever/fever reducer ■ if you are allergic to aspirin ■ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. ■ if you have ever had an allergic reaction to this product or any of its ingredients.
Ask a doctor before use
Ask a doctor before use if Ask a doctor before use if ■ stomach bleeding warning applies to you ■ you have a history of stomach problems such as heartburn ■ you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ■ you are taking a diuretic Ask a doctor before use if you have Ask a doctor before use if you have ■ asthma ■ glaucoma ■ diabetes ■ thyroid disease ■ trouble urinating due to an enlarged prostate gland ■ a breathing problem such as emphysema or chronic bronchitis ■ been placed on a sodium-restricted diet
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are Ask a doctor or pharmacist before use if you are ■ taking sedatives or tranquilizers ■ presently taking a prescription drug ■ taking a prescription drug for anticoagulation (thinning the blood), diabetes, gout or arthritis
When using this product
When using this product When using this product ■ do not exceed recommended dosage ■ you may get drowsy ■ avoid alcoholic drinks ■ excitability may occur, especially in children ■ alcohol, sedatives and tranquilizers may increase drowsiness ■ be careful when driving a motor vehicle or operating machinery
Stop use and ask a doctor
Stop use and ask a doctor if Stop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding ■ feel faint ■ vomit blood ■ have bloody or black stools ■ have stomach pain that does not get better ■ an allergic reaction occurs. Seek medical help right away ■ pain or nasal congestion gets worse or lasts more than 7 days ■ fever gets worse or lasts more than 3 days ■ new symptoms occur ■ redness or swelling is present ■ ringing in the ears or a loss of hearing occurs ■ nervousness, dizziness or sleeplessness occurs
Pregnancy or breast-feeding
If pregnant or breast-feeding If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
Keep out of reach of children.
Directions
Directions ■ do not use more than directed (see overdose warning) ■ adults and children 12 years and over: take 2 tablets completely dissolved in 4 oz of water every 4 hours ■ do not take more than 8 tablets in 24 hours ■ children under 12 years: ask a doctor
Inactive ingredients
Inactive Ingredients acesulfame potassium, anhydrous citric acid, aspartame, docusate sodium, FD&C red #40, FD&C yellow #6, flavors, mannitol, povidone, sodium benzoate, sodium bicarbonate
Questions?
Questions or comments? Call 1-888-228-6937 Distributed by: Distributed by: CVS Pharmacy, Inc. One CVS Drive, Woonsocket, RI 02895 CVS.com 1-800-SHOP CVS
Label text from the FDA structured product label by CVS Pharmacy, Inc. (revised Sep 4, 2025). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Phenylephrine Bitartrate in 4 products
- Aspirin in 4 products
- Chlorpheniramine Maleate in 4 products
Effervescent Orange Cold Relief NDC products (4)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 69842-875 | Phenylephrine Bitartrate 7.8 mg/1; Aspirin 325 mg/1; Chlorpheniramine Maleate 2 mg/1 Tablet, Effervescent | CVS Pharmacy, Inc. | OTC MONOGRAPH DRUG |
| 55910-769 | Phenylephrine Bitartrate 7.8 mg/1; Aspirin 325 mg/1; Chlorpheniramine Maleate 2 mg/1 Tablet, Effervescent | DOLGENCORP, LLC | OTC MONOGRAPH DRUG |
| 37808-768 | Phenylephrine Bitartrate 7.8 mg/1; Aspirin 325 mg/1; Chlorpheniramine Maleate 2 mg/1 Tablet, Effervescent | H. E. Butt Grocery Company | OTC MONOGRAPH DRUG |
| 41250-123 | Phenylephrine Bitartrate 7.8 mg/1; Aspirin 325 mg/1; Chlorpheniramine Maleate 2 mg/1 Tablet, Effervescent | Meijer Distribution Inc. | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Effervescent Orange Cold Relief used for?
Uses ■ temporarily relieves these symptoms due to the common cold: ■ sneezing ■ nasal congestion ■ sore throat ■ headache ■ minor aches and pains ■ runny nose ■ sinus congestion and pressure ■ temporarily reduces fever
Who makes Effervescent Orange Cold Relief?
Effervescent Orange Cold Relief is listed by 4 labelers in the FDA NDC directory, including CVS Pharmacy, Inc., DOLGENCORP, LLC, H. E. Butt Grocery Company, Meijer Distribution Inc..