Evara

Urea 40.5 Cream · Cream · Topical

Prescription (Rx)

Uses

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eshar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.

Dosage and administration

Apply Evara to affected skin twice per day, or as directed by your physician. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician.

Contraindications

This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product.

Warnings

Avoid contact with eyes, lips and mucous membranes.

Side effects

ADVERSE REACTIONS: Discontinue use and consult a physician if redness or irritation occurs.

How supplied

Evara Urea 40.5% Cream 8 oz. (227 g): NDC 85477-308-08

Label text from the FDA structured product label by Oncora Pharma, LLC (revised May 1, 2026). Long sections are shortened; the complete label is on DailyMed.

Active ingredients

Evara NDC products (1)

NDCStrength & formLabelerType
85477-308Urea 405 mg/g
Cream
Oncora Pharma, LLCUNAPPROVED DRUG OTHER

Frequently asked questions

What is Evara used for?

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eshar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and…

What are the side effects of Evara?

ADVERSE REACTIONS: Discontinue use and consult a physician if redness or irritation occurs. See the full label for the complete list.

Who makes Evara?

Evara is listed by 1 labeler in the FDA NDC directory, including Oncora Pharma, LLC.