Exaprin Plus
Aspirin, Acetaminophen, Caffeine · Tablet, Film Coated · Oral
Active ingredient
Active ingredients (in each caplet) Acetaminophen 250 mg Aspirin 250 mg (*nonsteroidal anti-inflammatory drug) Caffeine 65 mg
Purpose
Purpose Pain reliever Pain reliever Pain reliever aid
Uses
Uses temporarily relieves minor aches and pains due to: headache muscular aches minor arthritis pain backache common cold menstrual cramps toothache temporarily reduces fever
Warnings
Warning Reye’s syndrome : Children and teenagers should not use this medicine for chicken pox or flu symptoms before a doctor is consulted about Reye's syndrome, a rare but serious illness reported to be associated with asprin. Allergy alert: Aspirin may cause a severe allergic reaction which may include: hives facial swelling asthma (wheezing) shock Allergy alert: Acetaminophen may cause severe skin reactions which may include: rash blisters skin reddening Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: with other drugs containing acetaminophen more than 4,000 mg of acetaminophen in 24 hours 3 or more alcoholic drinks every day while using this product Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take more or for a longer time than directed take a blood thinning (anticoagulant) or steroid drug have 3 or more alcoholic drinks every day while using this product take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) Do not use if you have ever had an allergic reaction to any other pain reliever/fever reducer with any other drug containing acetaminophen (prescription or nonprescription). Ask a doctor before use if you have asthma, high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have a history of stomach problems, such as heartburn stomach bleeding warning applies you Ask a doctor or pharmacist before use if you take any drug for diabetes, gout, or arthritis take any drug containing an NSAID you do not know if other drugs you are taking contain acetaminophen Stop use and ask a doctor if an allergic reaction occurs, seek medical help right away new symptoms occur redness or swelling is present ringing in the ears or loss of hearing occurs fever gets worse or lasts more than 3 days pain gets worse or lasts more than 10 days you have any of the following signs of stomach bleeding: feel faint, vomit blood, have bloody or black stools, or stomach pain that does not get better. These could be signs of a serious condition If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. Overdose warning taking more than the recommended dose (overdose) may cause liver damage. Quick medical attention is critical for adult as well as for children even if you do not notice any signs or symptoms. In case of overdose, get medical help or contact a Poison Control Center right away. 1-800-222-1222
Do not use
Do not use if you have ever had an allergic reaction to any other pain reliever/fever reducer with any other drug containing acetaminophen (prescription or nonprescription).
Ask a doctor before use
Ask a doctor before use if you have asthma, high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have a history of stomach problems, such as heartburn stomach bleeding warning applies you
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you take any drug for diabetes, gout, or arthritis take any drug containing an NSAID you do not know if other drugs you are taking contain acetaminophen
Stop use and ask a doctor
Stop use and ask a doctor if an allergic reaction occurs, seek medical help right away new symptoms occur redness or swelling is present ringing in the ears or loss of hearing occurs fever gets worse or lasts more than 3 days pain gets worse or lasts more than 10 days you have any of the following signs of stomach bleeding: feel faint, vomit blood, have bloody or black stools, or stomach pain that does not get better. These could be signs of a serious condition
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
Keep out of reach of children.
Directions
Directions do not take more than directed Adults and children 12 years of age and over: take 2 caplets with water every 6 hours while symptoms persist do not take more than 8 caplets in 24 hours unless directed by a doctor. Children under 12 years of age: ask a doctor
Other information
Other information caplets enclosed in a sealed packet do not use if packet is torn, cut, or open store at 59° to 86°F (15°-30°C) avoid excessive heat and humidity
Inactive ingredients
Inactive ingredients corn starch, crospovidone, hypromellose, microcrystalline cellulose, povidone, propylene glycol, sodium lauryl sulfate, sodium starch glycolate, stearic acid, titanium dioxide
Label text from the FDA structured product label by HART Health (revised Aug 4, 2025). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 1 product
- Aspirin in 1 product
- Caffeine in 1 product
Exaprin Plus NDC products (1)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 50332-0144 | Acetaminophen 250 mg/1; Aspirin 250 mg/1; Caffeine 65 mg/1 Tablet, Film Coated | HART Health | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Exaprin Plus used for?
Uses temporarily relieves minor aches and pains due to: headache muscular aches minor arthritis pain backache common cold menstrual cramps toothache temporarily reduces fever
Who makes Exaprin Plus?
Exaprin Plus is listed by 1 labeler in the FDA NDC directory, including HART Health.