Multi Symptom Cold and Multi Symptom Nighttime Cold
Dextromethorphan HBr, Guaifenesin, Phenylephrine HCI, Acetaminophen, Diphenhydramine HCI, Phenylephrine HCI · Kit
Active ingredient
Active ingredients for Nighttime (in each 10 mL) Acetaminophen 325 mg Diphenhydramine HCI 12.5 mg Phenylephrine HCI 5 mg Active ingredients for Daytime (in each 5 mL) Dextromethorphan HBr 5 mg Guaifenesin 100 mg Phenylephrine HCl 2.5 mg
Purpose
Purpose for Nighttime Pain reliever / fever reducer Antihistamine / Cough suppressant Nasal Decongestant Purpose for Daytime Cough suppressant Expectorant Nasal decongestant
Uses
Uses Nighttime temporarily relieves these common cold and flu symptoms minor aches and pains headache sore throat sneezing runny nose nasal congestion cough controls cough to help your child get to sleep temporarily reduces fever Daytime helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make cough more productive temporarialy relieves cough due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants the intensity of coughing the impulse to cough to help your child get to sleep nasal congestion due to a cold stuffy nose
Warnings
Warnings NIGHTTIME Liver warning : This product contains acetaminophen. Severe liver damage may occur if your child takes: more than 5 doses in 24 hours, which is the maximum daily amount with other drugs containing acetaminophen Allergy alert : Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning : If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea,or vomiting, consult a doctor promptly. Do not use Nighttime with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist in a child who is taking prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child's prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product with any other drug containing diphenhydramine, even one used on skin. If your child is allergic to acetaminophen or any of the inactive ingredients in this product to make a child sleepy Daytime in a child who is taking a prescription monoamine oxidase inhibitor (MAOI)(certain drugs for depression,psychiatic or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product. Ask a doctor before use if you have Nighttime liver disease heart disease thyroid disease diabetes glaucoma high blood pressure a breathing problem such as chronic bronchitis persistent or chronic cough such as occurs with asthma cough that occurs with too much phlegm (mucus) Daytime heart disease high blood pressure thyroid disease diabetes cough that occurs with too much phlegm (mucus) persistent or chronic cough such as occurs with asthma Ask a doctor or pharmacist before use if you are Nighttime taking the blood thinning drug warfain taking sedative or tranquilizers When using these products Nighttime do not use more than directed marked drowsiness may occur excitablity may occur, especially in children sedatives and tranquilizer may increase drowsiness Daytime do not use more than directed Stop use and ask a doctor if Nighttime nervousness, dizziness, or sleeplessness occur pain, nasal congestion, or cough gets worse or last more than 5 days redness or swelling is present new symptoms occurs fever gets worse or lasts more than 3 days cough comes back or occurs with rash or headache that lasts. These could be signs of a serious conditions. Daytime nervousness, dizziness or sleeplessness occur symptoms do not better within 7 days or occur with fever cough lasts more than 7 days, comes back or occur with a fever, rash, or headache that lasts. These could be signs of a serious condition. Keep out of reach of children. Nighttime Overdose warning : Taking more than the recommended dose (overdose) may cause liver damage.In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical even if you do not notice any sign or symptoms. Daytime In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
Do not use
Do not use Nighttime with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist in a child who is taking prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child's prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product with any other drug containing diphenhydramine, even one used on skin. If your child is allergic to acetaminophen or any of the inactive ingredients in this product to make a child sleepy Daytime in a child who is taking a prescription monoamine oxidase inhibitor (MAOI)(certain drugs for depression,psychiatic or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product.
Ask a doctor before use
Ask a doctor before use if you have Nighttime liver disease heart disease thyroid disease diabetes glaucoma high blood pressure a breathing problem such as chronic bronchitis persistent or chronic cough such as occurs with asthma cough that occurs with too much phlegm (mucus) Daytime heart disease high blood pressure thyroid disease diabetes cough that occurs with too much phlegm (mucus) persistent or chronic cough such as occurs with asthma
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are Nighttime taking the blood thinning drug warfain taking sedative or tranquilizers
When using this product
When using these products Nighttime do not use more than directed marked drowsiness may occur excitablity may occur, especially in children sedatives and tranquilizer may increase drowsiness Daytime do not use more than directed
Stop use and ask a doctor
Stop use and ask a doctor if Nighttime nervousness, dizziness, or sleeplessness occur pain, nasal congestion, or cough gets worse or last more than 5 days redness or swelling is present new symptoms occurs fever gets worse or lasts more than 3 days cough comes back or occurs with rash or headache that lasts. These could be signs of a serious conditions. Daytime nervousness, dizziness or sleeplessness occur symptoms do not better within 7 days or occur with fever cough lasts more than 7 days, comes back or occur with a fever, rash, or headache that lasts. These could be signs of a serious condition.
Keep out of reach of children
Keep out of reach of children. Nighttime Overdose warning : Taking more than the recommended dose (overdose) may cause liver damage.In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical even if you do not notice any sign or symptoms. Daytime In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
Directions
Directions Nighttime this product does not contain directions or complete warnings for adult use do not give more than directed (see Overdose warning) do not give more than 5 doses in any 24-hour period if needed, repeat dose every 4 hours while symptoms last do not give more than 5 days unless directed by a doctor measure only with dosing cup provided. Do not use any other dosing device. mL = milliliter dose as follows or as directed by a doctor children 6 to under 12 years of age : 10 mL every 4 hours children under 6 years of age : do not use Daytime do not take more than 6 doses in any 24-hours period use only the enclosed dosing cup designed for use with this product. Do not use any other dosing device keep dosing cup with product dose as follows, or as directed by a doctor mL = milliliter Age Dose children 6 years to under 12 years 10 mL every 4 hours children 4 years to under 6 years 5 mL every 4 hours children under 4 years do not use
Other information
Other information Nighttime each 10 mL contains : sodium 6 mg store between 20-25ºC (68-77ºF). Do not refrigerate. Daytime each 5 mL contains : 5 mg store between 20-25ºC (68-77ºF). Do not refrigerate.
Inactive ingredients
Inactive ingredients Nighttime citric acid, disodium EDTA, FD&C Blue #1, FD&C red #40, Flavor, glycerin, propyl gallate, propylene glycol, purified water, sodium benzoate, sodium citrate, sorbitol, sucralose, xanthan gum Daytime citric acid, disodium EDTA, FD&C red #40, flavor, glycerin, propyl gallate, propylene glycol, purified water, sodium benzoate, sodium citrate, sorbitol, sucralose xanthan gum
Questions?
Questions or comments? Call 1-877-753-3935 Monday-Friday 9AM-5PM EST
Label text from the FDA structured product label by CVS Pharmacy (revised Sep 12, 2025). Long sections are shortened; the complete label is on DailyMed.
Multi Symptom Cold and Multi Symptom Nighttime Cold NDC products (2)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 69842-820 | Kit | CVS Pharmacy | OTC MONOGRAPH DRUG |
| 11673-420 | Kit | TARGET Corporation | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Multi Symptom Cold and Multi Symptom Nighttime Cold used for?
Uses Nighttime temporarily relieves these common cold and flu symptoms minor aches and pains headache sore throat sneezing runny nose nasal congestion cough controls cough to help your child get to sleep temporarily reduces fever Daytime helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make cough more productive temporarialy…
Who makes Multi Symptom Cold and Multi Symptom Nighttime Cold?
Multi Symptom Cold and Multi Symptom Nighttime Cold is listed by 2 labelers in the FDA NDC directory, including CVS Pharmacy, TARGET Corporation.