Norepinephrine
Norepinephrine Bitartrate · Liquid · Oral, Intravenous
Uses
Norepinephrine in Sodium Chloride Injection is indicated to raise blood pressure in adult patients with severe, acute hypotension. Norepinephrine in Sodium Chloride Injection is a catecholamine indicated for restoration of blood pressure in adult patients with acute hypotensive states. ( 1 )
Dosage and administration
No further dilution prior to infusion is required ( 2.1 ) Initial intravenous infusion rate of 8 to 12 mcg per minute, adjust the rate of flow to establish and maintain a low to normal blood pressure (usually 80 to 100 mm Hg) sufficient to maintain the circulation of vital organs ( 2.2 ) The average maintenance dose ranges from 2 to 4 mcg per minute. ( 2.2 ) 2.1 Important Dosage and Administration Instructions Correct Hypovolemia Address hypovolemia before initiation of Norepinephrine in Sodium Chloride Injection therapy. If the patient does not respond to therapy, suspect occult hypovolemia [see Warnings and Precautions ( 5.1 )] . Administration Infuse Norepinephrine in Sodium Chloride Injection into a large vein. Avoid infusions into the veins of the leg in the elderly or in patients with occlusive vascular disease of the legs [see Warnings and Precautions ( 5.1 )] . Avoid using a catheter-tie-in technique. Inspect parenteral drug products for particulate matter and discoloration prior to use, whenever solution and container permit. Do not open the aluminum foil pouch until time of use. The premixed, ready-to-use infusion bag has a single port for insertion of the infusion set only. Do not use this port to remove content from the bag or add another medication. Once the infusion bag has been connected to the infusion set, it is stable for 24 hours for intermittent or continuous use, as long as the bag stays connected to the infusion set. Discontinuation When discontinuing the infusion, reduce the flow rate gradually. Avoid abrupt withdrawal. Single dose only. Discard unused portion. 2.2 Dosage After an initial dose of 8 to 12 mcg per minute via intravenous infusion, assess patient response and adjust dosage to maintain desired hemodynamic effect. Monitor blood pressure every two minutes or continuously until the desired hemodynamic effect is achieved, and then monitor blood pressure every five minutes for the duration of the infusion. Recommended Average Maintenance Dosage: Typical maintenance intravenous dosage is 2 to 4 mcg per minute. 2.3 Drug Incompatibilities Avoid contact with iron salts and alkalizing and oxidizing agents. Whole blood or plasma, if indicated to increase blood volume, should be administered separately.
Label text from the FDA structured product label by Long Grove Pharmaceuticals, LLC (revised Dec 4, 2025). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Norepinephrine Bitartrate in 4 products
- Norepinephrine in 3 products
Norepinephrine NDC products (7)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 81298-9655 | Norepinephrine Bitartrate 32 ug/mL Solution | Long Grove Pharmaceuticals, LLC | NDA |
| 81298-9658 | Norepinephrine Bitartrate 64 ug/mL Solution | Long Grove Pharmaceuticals, LLC | NDA |
| 81298-9659 | Norepinephrine Bitartrate 16 ug/mL Solution | Long Grove Pharmaceuticals, LLC | NDA |
| 43857-0161 | Norepinephrine 6 [hp_X]/mL Liquid | BioActive Nutritional, Inc. | UNAPPROVED HOMEOPATHIC |
| 43857-0260 | Norepinephrine 6 [hp_X]/mL Liquid | BioActive Nutritional, Inc. | UNAPPROVED HOMEOPATHIC |
| 43742-1489 | Norepinephrine Bitartrate 8 [hp_X]/mL Liquid | Deseret Biologicals, Inc. | UNAPPROVED HOMEOPATHIC |
| 63083-1530 | Norepinephrine 9 [hp_X]/29.5mL Liquid | Professional Complementary Health Formulas | UNAPPROVED HOMEOPATHIC |
Frequently asked questions
What is Norepinephrine used for?
Norepinephrine in Sodium Chloride Injection is indicated to raise blood pressure in adult patients with severe, acute hypotension. Norepinephrine in Sodium Chloride Injection is a catecholamine indicated for restoration of blood pressure in adult patients with acute hypotensive states. ( 1 )
Who makes Norepinephrine?
Norepinephrine is listed by 4 labelers in the FDA NDC directory, including Long Grove Pharmaceuticals, LLC, BioActive Nutritional, Inc., Deseret Biologicals, Inc., Professional Complementary Health Formulas.