Overnight Cold and Flu
Acetaminophen, Dextromethorphan HBr, Triprolidine HCl · Solution · Oral
Active ingredient
Active ingredients (in each 20 mL) Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Triprolidine HCl 2.5 mg Antihistamine
Purpose
Active ingredients (in each 20 mL) Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Triprolidine HCl 2.5 mg Antihistamine
Uses
Uses ▪ temporarily relieves these common cold and flu symptoms: ▪ cough ▪ minor aches and pains ▪ sore throat ▪ headache ▪ runny nose ▪ sneezing ▪ itching of the nose or throat ▪ itchy, watery eyes due to hay fever ▪ temporarily reduces fever ▪ controls cough to help you get to sleep
Warnings
Warnings Liver warning This product contains acetaminophen. Severe liver damage may occur if you take: ▪ more than 4000 mg in 24 hours, which is the maximum daily amount ▪ with other drugs containing acetaminophen ▪ 3 or more alcoholic drinks daily while using this product Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include: ▪ skin reddening ▪ blisters ▪ rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. ▪ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have ▪ liver disease ▪ glaucoma ▪ trouble urinating due to an enlarged prostate gland ▪ a breathing problem such as emphysema or chronic bronchitis ▪ persistent or chronic cough such as occurs with smoking, asthma, or emphysema ▪ cough that occurs with too much phlegm (mucus) Ask a doctor or pharmacist before use if you are ▪ taking the blood thinning drug warfarin ▪ taking sedatives or tranquilizers When using this product ▪ do not use more than directed ▪ excitability may occur, especially in children ▪ marked drowsiness may occur ▪ alcohol, sedatives, and tranquilizers may increase drowsiness ▪ avoid alcoholic drinks ▪ use caution when driving a motor vehicle or operating machinery Stop use and ask a doctor if ▪ pain or cough gets worse or lasts more than 7 days ▪ fever gets worse or lasts more than 3 days ▪ redness or swelling is present ▪ new symptoms occur ▪ cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Overdose warning Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Do not use
Do not use ▪ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. ▪ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use
Ask a doctor before use if you have ▪ liver disease ▪ glaucoma ▪ trouble urinating due to an enlarged prostate gland ▪ a breathing problem such as emphysema or chronic bronchitis ▪ persistent or chronic cough such as occurs with smoking, asthma, or emphysema ▪ cough that occurs with too much phlegm (mucus)
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are ▪ taking the blood thinning drug warfarin ▪ taking sedatives or tranquilizers
When using this product
When using this product ▪ do not use more than directed ▪ excitability may occur, especially in children ▪ marked drowsiness may occur ▪ alcohol, sedatives, and tranquilizers may increase drowsiness ▪ avoid alcoholic drinks ▪ use caution when driving a motor vehicle or operating machinery
Stop use and ask a doctor
Stop use and ask a doctor if ▪ pain or cough gets worse or lasts more than 7 days ▪ fever gets worse or lasts more than 3 days ▪ redness or swelling is present ▪ new symptoms occur ▪ cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition.
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children.
Directions
Directions ▪ do not take more than directed (see Overdose warning ) ▪ do not take more than 4 doses in any 24-hour period ▪ measure only with dosing cup provided ▪ do not use dosing cup with other products ▪ dose as follows or as directed by a doctor ▪ adults and children 12 years of age and older: 20 mL in dosing cup provided every 4 hours ▪ children under 12 years of age: do not use
Other information
Other information ▪ each 20 mL contains: sodium 10 mg ▪ low sodium ▪ store at room temperature ▪ do not refrigerate
Inactive ingredients
Inactive ingredients anhydrous citric acid, ascorbic acid, edetate disodium, FD&C Blue No. 1, FD&C Red No. 40, flavors, glycerin, propyl gallate, propylene glycol, purified water, sodium benzoate, sodium citrate, sorbitol, sucralose, xanthan gum
Questions?
Questions or comments? 1-866-467-2748
Label text from the FDA structured product label by RARITAN PHARMACEUTICALS (revised Sep 8, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 2 products
- Dextromethorphan Hydrobromide in 2 products
- Triprolidine Hydrochloride in 2 products
Overnight Cold and Flu NDC products (2)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 68163-698 | Acetaminophen 650 mg/20mL; Dextromethorphan Hydrobromide 20 mg/20mL; Triprolidine Hydrochloride 2.5 mg/20mL Solution | RARITAN PHARMACEUTICALS | OTC MONOGRAPH DRUG |
| 0363-6980 | Acetaminophen 650 mg/20mL; Dextromethorphan Hydrobromide 20 mg/20mL; Triprolidine Hydrochloride 2.5 mg/20mL Solution | WALGREENS CO | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Overnight Cold and Flu used for?
Uses ▪ temporarily relieves these common cold and flu symptoms: ▪ cough ▪ minor aches and pains ▪ sore throat ▪ headache ▪ runny nose ▪ sneezing ▪ itching of the nose or throat ▪ itchy, watery eyes due to hay fever ▪ temporarily reduces fever ▪ controls cough to help you get to sleep
Who makes Overnight Cold and Flu?
Overnight Cold and Flu is listed by 2 labelers in the FDA NDC directory, including RARITAN PHARMACEUTICALS, WALGREENS CO.