Relief-PE
Acetaminophen, Phenylephrine, Chlorpheniramine · Tablet, Coated · Oral
Active ingredient
Active Ingredients (in each tablet): Acetaminophen 325mg Phenylephrine HCl 5mg Chlorpheniramine Maleate 2mg
Purpose
Purpose: Pain Reliever/Fever Reducer Antihistamine Nasal Decongestant
Uses
Temporarily relieves nasal congestion, sinus pressure, and minor aches and pains due to: the common cold hay fever upper respiratory allergies headache itchy/watery eyes runny nose muscular aches Temporarily reduces fever
Warnings
Liver warning: this product contains acetaminophen. Severe liver damage may occur if you take: more than 4000mg of acetaminophen 24 hours with other drugs containing acetaminophen 3 or more alcohol drinks every day while using this product Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash
Do not use
Do not use: with any other drug containing acetaminophen (prescription or non-prescription) if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug, or if you do not know if your prescription drug contains an MAOI
Ask a doctor before use
Ask a doctor before use if you have heart, liver, or thyroid disease high blood pressure diabetes glaucoma trouble urinating due to an enlarged prostate gland a breathing problem such as emphysema or chronic bronchitis
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers you are taking the blood thinning drug warfarin you do not know if other drugs you are taking contain acetaminophen
When using this product
When using this product to not use more than directed. This product may cause excitability or drowsiness. Alcohol, sedatives and tranquilizers may increase the drowsiness effect. Use caution when driving a motor vehicle or operating machinery.
Stop use and ask a doctor
Stop use and ask a doctor if an allergic reaction occurs, seek medical help right away you get nervous, dizzy or sleepless new symptom occur fever worsens or lasts for more than 3 days pain or nasal congestion gets worse or lasts more than 7 days redness or swelling is present These could be signs of serious condition
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children.
Directions
Directions: Do not take more than directed . Adults and children 12 years of age an over: take 1 to 2 tablets every 6 hours while symptoms persist do not take more than 8 tablets in 24 hours unless directed by a doctor Children under 12 years of age: ask a doctor
Inactive ingredients
corn starch, crospovidone, hypromellose, microcrystalline cellulose, polyethylene glycol, povidone, pregelantined starch, stearic acid
Label text from the FDA structured product label by HART Health (revised Jan 15, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 1 product
- Phenylephrine Hydrochloride in 1 product
- Chlorpheniramine Maleate in 1 product
Relief-PE NDC products (1)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 50332-0153 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1; Chlorpheniramine Maleate 2 mg/1 Tablet, Coated | HART Health | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Relief-PE used for?
Temporarily relieves nasal congestion, sinus pressure, and minor aches and pains due to: the common cold hay fever upper respiratory allergies headache itchy/watery eyes runny nose muscular aches Temporarily reduces fever
Who makes Relief-PE?
Relief-PE is listed by 1 labeler in the FDA NDC directory, including HART Health.