Sinus Pressure plus Pain PE
ACETAMINOPHEN and PHENYLEPHRINE HYDROCHLORIDE · Tablet, Coated · Oral
Active ingredient
Active ingredients (in each caplet) Purpose Acetaminophen 325 mg Pain reliever/fever reducer Phenylephrine HCl 5 mg Nasal decongestant
Purpose
Active ingredients (in each caplet) Purpose Acetaminophen 325 mg Pain reliever/fever reducer Phenylephrine HCl 5 mg Nasal decongestant
Uses
Uses temporarily relieves these symptoms associated with hay fever or other upper respiratory allergies, and the common cold: sinus congestion and pressure headache minor aches and pains nasal congestion promotes sinus drainage temporarily reduces fever
Warnings
Warnings Liver warning This product contains acetaminophen. The maximum daily dose of this product is 10 caplets (3,250 mg acetaminophen) in 24 hours. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have liver disease heart disease high blood pressure thyroid disease diabetes trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin When using this product do not exceed recommended dosage Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur pain or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Overdose warning In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Do not use
Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use
Ask a doctor before use if you have liver disease heart disease high blood pressure thyroid disease diabetes trouble urinating due to an enlarged prostate gland
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin
When using this product
When using this product do not exceed recommended dosage
Stop use and ask a doctor
Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur pain or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur These could be signs of a serious condition.
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children.
Directions
Directions do not take more than directed (see overdose warning ) adults and children 12 years and over take 2 caplets every 4 hours do not take more than 10 caplets in 24 hours children under 12 years ask a doctor
Other information
Other information store between 20-25ºC (68-77ºF) in a dry place retain carton for complete product information and warnings
Inactive ingredients
Inactive ingredients colloidal silicon dioxide, corn starch, croscarmellose sodium, crospovidone, FD&C yellow #6 aluminum lake, iron oxide yellow, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, pregelatinized starch, stearic acid, talc, titanium dioxide
Questions?
Questions or comments? 1-844-705-4384
Label text from the FDA structured product label by VALU MERCHANDISERS COMPANY (revised Dec 11, 2025). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Acetaminophen in 6 products
- Phenylephrine Hydrochloride in 6 products
Sinus Pressure plus Pain PE NDC products (6)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 53943-220 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | DISCOUNT DRUG MART | OTC MONOGRAPH DRUG |
| 72036-320 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | Harris Teeter | OTC MONOGRAPH DRUG |
| 68998-220 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | MARC GLASSMAN, INC. | OTC MONOGRAPH DRUG |
| 72476-120 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | RETAIL BUSINESS SERVICES , LLC. | OTC MONOGRAPH DRUG |
| 36800-320 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | TOPCO ASSOCIATES LLC | OTC MONOGRAPH DRUG |
| 63941-220 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet, Coated | VALU MERCHANDISERS COMPANY | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Sinus Pressure plus Pain PE used for?
Uses temporarily relieves these symptoms associated with hay fever or other upper respiratory allergies, and the common cold: sinus congestion and pressure headache minor aches and pains nasal congestion promotes sinus drainage temporarily reduces fever
Who makes Sinus Pressure plus Pain PE?
Sinus Pressure plus Pain PE is listed by 6 labelers in the FDA NDC directory, including DISCOUNT DRUG MART, Harris Teeter, MARC GLASSMAN, INC., RETAIL BUSINESS SERVICES , LLC..