Sinus Relief
Acetaminophen, Diphenhydramine HCl, Guaifenesin, Phenylephrine HCl · Kit · Oral, Sublingual
Active ingredient
Active ingredients (in each caplet) (Sinus day) Acetaminophen 325 mg Guaifenesin 200 mg Phenylephrine HCl 5 mg Active ingredients (in each caplet) (Sinus night) Acetaminophen 325 mg Diphenhydramine HCl 12.5 mg Phenylephrine HCl 5 mg
Purpose
Purpose Pain reliever Expectorant Nasal decongestant Purpose Pain reliever Antihistamine/cough suppressant Nasal decongestant
Uses
Uses temporarily relieves these common cold symptoms: nasal congestion headache minor aches and pains sinus congestion and pressure cough (Nighttime only) runny nose and sneezing (Nighttime only) temporarily promotes nasal and/or sinus drainage helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive (Daytime only)
Warnings
Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients with any other product containing diphenhydramine, even one used on skin (Nighttime only) Ask a doctor before use if you have heart disease high blood pressure liver disease thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema cough that occurs with too much phlegm (mucus) a breathing problem such as emphysema or chronic bronchitis (Nighttime only) glaucoma (Nighttime only) Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers (Nighttime only) When using this product do not exceed recommended dosage excitability may occur, especially in children (Nighttime only) marked drowsiness may occur (Nighttime only) alcohol, sedatives, and tranquilizers may increase drowsiness (Nighttime only) use caution when driving a motor vehicle or operating machinery (Nighttime only) avoid alcoholic beverages (Nighttime only) Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur pain, nasal congestion, or cough gets worse or lasts more than 7 days new symptoms occur fever gets worse or lasts more than 3 days redness or swelling is present cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms. Do not take DAYTIME and NIGHTTIME products at the same time.
Do not use
Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients with any other product containing diphenhydramine, even one used on skin (Nighttime only)
Ask a doctor before use
Ask a doctor before use if you have heart disease high blood pressure liver disease thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema cough that occurs with too much phlegm (mucus) a breathing problem such as emphysema or chronic bronchitis (Nighttime only) glaucoma (Nighttime only)
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers (Nighttime only)
When using this product
When using this product do not exceed recommended dosage excitability may occur, especially in children (Nighttime only) marked drowsiness may occur (Nighttime only) alcohol, sedatives, and tranquilizers may increase drowsiness (Nighttime only) use caution when driving a motor vehicle or operating machinery (Nighttime only) avoid alcoholic beverages (Nighttime only)
Stop use and ask a doctor
Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur pain, nasal congestion, or cough gets worse or lasts more than 7 days new symptoms occur fever gets worse or lasts more than 3 days redness or swelling is present cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
Pregnancy or breast-feeding
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms. Do not take DAYTIME and NIGHTTIME products at the same time.
Directions
Directions do not take more than directed do not take more than 12 caplets in any 24-hour period adults and children 12 years and over: take 2 caplets every 4 hours children under 12 years: do not use
Other information
Other information each caplet contains: sodium 3 mg (Daytime only) TAMPER EVIDENT: DO NOT USE IF OUTER PACKAGE IS OPENED OR BLISTER IS TORN OR BROKEN store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) see end flap for expiration date and lot number
Inactive ingredients
Inactive ingredients (Daytime only) corn starch, crospovidone, FD&C red #40 aluminum lake, FD&C yellow #6 aluminum lake, magnesium stearate, maltodextrin, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, sodium starch glycolate, stearic acid, talc, titanium dioxide Inactive ingredients (Nighttime only) corn starch, croscarmellose sodium, crospovidone, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, iron oxide yellow, magnesium stearate, methacrylic acid and ethyl acrylate copolymer, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, sodium bicarbonate, stearic acid, talc, titanium dioxide
Questions?
Questions or comments? 1-800-426-9391
Label text from the FDA structured product label by Rite Aid Corporation (revised Jul 30, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Calcium Sulfide in 2 products
- Potassium Dichromate in 2 products
- Acetaminophen in 1 product
- Phenylephrine Hydrochloride in 1 product
- Apis Mellifera in 1 product
- Baptisia Tinctoria Root in 1 product
- Citrullus Colocynthis Fruit Pulp in 1 product
- Histamine Dihydrochloride in 1 product
- Goldenseal in 1 product
- Strychnos Ignatii Seed in 1 product
- Potassium Iodide in 1 product
- Lemna Minor Whole in 1 product
Sinus Relief NDC products (6)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 21130-502 | Acetaminophen 325 mg/1; Phenylephrine Hydrochloride 5 mg/1 Tablet | Better Living Brands, LLC | OTC MONOGRAPH DRUG |
| 69842-882 | Kit | CVS PHARMACY | OTC MONOGRAPH DRUG |
| 30142-616 | Kit | Kroger Company | OTC MONOGRAPH DRUG |
| 11822-5694 | Kit | Rite Aid Corporation | OTC MONOGRAPH DRUG |
| 61727-335 | Asafetida 8 [hp_X]/4g; Echinacea Angustifolia 12 [hp_X]/4g; Calcium Sulfide 8 [hp_X]/4g; Potassium Dichromate 18… Pellet | Homeocare Laboratories | UNAPPROVED HOMEOPATHIC |
| 57955-9969 | Apis Mellifera 10 [hp_X]/59mL; Baptisia Tinctoria Root 10 [hp_X]/59mL; Citrullus Colocynthis Fruit Pulp 10 [hp_X]/59mL;… Liquid | King Bio Inc. | UNAPPROVED HOMEOPATHIC |
Frequently asked questions
What is Sinus Relief used for?
Uses temporarily relieves these common cold symptoms: nasal congestion headache minor aches and pains sinus congestion and pressure cough (Nighttime only) runny nose and sneezing (Nighttime only) temporarily promotes nasal and/or sinus drainage helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive (Daytime…
Who makes Sinus Relief?
Sinus Relief is listed by 6 labelers in the FDA NDC directory, including Better Living Brands, LLC, CVS PHARMACY, Kroger Company, Rite Aid Corporation.