Tusslin

Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine Hydrochloride · Syrup · Oral

Over the counter Expectorant Sigma-1 Agonist Uncompetitive N-methyl-D-aspartate Receptor Antagonist

Active ingredient

Active ingredients (in each 5 mL 1 teaspoonful) Dextromethorphan HBr 20 mg Guaifenesin 388 mg Phenylephrine HCl 10 mg

Purpose

Purpose Cough suppressant Expectorant Nasal decongestant

Uses

Uses
• temporarily relieves cough due to minor throat and bronchial irritation occurring with a cold or inhaled irritants
• helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive
• temporarily relieves nasal congestion due to a cold

Warnings

Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have
• diabetes
• heart disease
• thyroid disease
• high blood pressure
• trouble urinating due to an enlarged prostate gland
• cough that occurs with too much phlegm (mucus)
• cough that lasts or is chronic such as occurs with smoking, asthma, chronic bronchitis or emphysema. When using this product do not use more than directed. Stop use and ask a doctor if
• you get nervous, dizzy, or sleepless
• symptoms do not get better within 7 days or are accompanied by fever
• cough lasts for more than 7 days, comes back, or is accompanied by fever, rash, or persistent headache. These could be signs of a serious condition. If pregnant or breast-feeding , ask a health professional before use. Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away.

Keep out of reach of children

Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

Directions
• do not take more than 6 doses in any 24-hour period
• mL = milliliter, tsp = teaspoon adults and children 12 years of age and over 5 mL (1 teaspoon) every 4 hours children under 12 years of age do not use

Other information

Other information
• tamper evident feature: do not use if printed security seal is torn, broken or missing.
• store at controlled room temperature 15-30ºC (59-86ºF)
• avoid excessive heat or humidity.

Inactive ingredients

Inactive ingredients citric acid, flavor, glycerin, methylparaben, propylene glycol, propylparaben, purified water, sodium chloride, sodium citrate, sucralose

Questions?

Questions or comments? 1-787-767-2072 You may also report serious side effects to this phone number . Call weekdays from 8:00 am to 4:00 pm AST

Label text from the FDA structured product label by Kramer Novis (revised Dec 3, 2025). Long sections are shortened; the complete label is on DailyMed.

Active ingredients

Tusslin NDC products (1)

NDCStrength & formLabelerType
52083-624Dextromethorphan Hydrobromide 20 mg/5mL; Guaifenesin 388 mg/5mL; Phenylephrine Hydrochloride 10 mg/5mL
Syrup
Kramer NovisOTC MONOGRAPH DRUG

Frequently asked questions

What is Tusslin used for?

Uses • temporarily relieves cough due to minor throat and bronchial irritation occurring with a cold or inhaled irritants • helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive • temporarily relieves nasal congestion due to a cold

Who makes Tusslin?

Tusslin is listed by 1 labeler in the FDA NDC directory, including Kramer Novis.