Up and Up
Salicylic Acid · Liquid · Topical, Rectal, Oral
Active ingredient
Active ingredient Phenylephrine HCl 0.25%
Purpose
Purpose Vasoconstrictor
Uses
Uses helps relieve the local itching and discomfort associated with hemorrhoids temporarily shrinks hemorrhoidal tissue temporarily reduces the swelling associated with irritation in hemorrhoids and other anorectal disorders
Warnings
Warnings For rectal use only Ask a doctor before use if you have heart disease high blood pressure thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland Ask a doctor or pharmacist before use if you are presently taking a prescription drug for high blood pressure or depression When using this product do not exceed the recommended daily dosage unless directed by a doctor. Stop use and ask a doctor if bleeding occurs condition worsens or does not improve within 7 days If pregnant or breast feeding ask a health professional before use. Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.
Ask a doctor before use
Ask a doctor before use if you have heart disease high blood pressure thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland
Ask a doctor or pharmacist
Ask a doctor or pharmacist before use if you are presently taking a prescription drug for high blood pressure or depression
When using this product
When using this product do not exceed the recommended daily dosage unless directed by a doctor.
Stop use and ask a doctor
Stop use and ask a doctor if bleeding occurs condition worsens or does not improve within 7 days
Pregnancy or breast-feeding
If pregnant or breast feeding ask a health professional before use.
Keep out of reach of children
Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.
Directions
Directions adults: when practical, cleanse the affected area by patting or blotting with an appropriate cleansing wipe. Gently dry by patting or blotting with a tissue or a soft cloth before insertion of this product. detach one suppository from the strip; remove the foil wrapper before inserting into the rectum as follows: hold suppository with the rounded end up carefully separate foil tabs by inserting tip of fingernail at end marked “peel down” slowly and evenly peel apart (do not tear) foil by pulling tabs down both sides, to expose the suppository remove exposed suppository from the wrapper insert one suppository into the rectum up to 4 times daily, especially at night, in the morning or after each bowel movement children under 12 years of age: consult a doctor
Inactive ingredients
Inactive ingredients cocoa butter, corn starch, methylparaben, propylparaben
Questions?
Questions or comments? call 800-910-6874
Label text from the FDA structured product label by Target Corporation (revised Jul 29, 2026). Long sections are shortened; the complete label is on DailyMed.
Active ingredients
- Salicylic Acid in 3 products
- Phenylephrine Hydrochloride in 2 products
- Acetaminophen in 1 product
- Diphenhydramine Hydrochloride in 1 product
- Octisalate in 1 product
- Octinoxate in 1 product
- Avobenzone in 1 product
- Benzalkonium Chloride in 1 product
Up and Up NDC products (7)
| NDC | Strength & form | Labeler | Type |
|---|---|---|---|
| 11673-024 | Salicylic Acid 20 mg/mL Liquid | TARGET CORPORATION | OTC MONOGRAPH DRUG |
| 11673-113 | Acetaminophen 650 mg/1; Diphenhydramine Hydrochloride 25 mg/1; Phenylephrine Hydrochloride 10 mg/1 Powder, For Solution | Target Corporation | OTC MONOGRAPH DRUG |
| 11673-930 | Salicylic Acid 20 mg/g Emulsion | TARGET CORPORATION | OTC MONOGRAPH DRUG |
| 11673-934 | Octisalate 20 mg/mL; Octinoxate 75 mg/mL; Avobenzone 30 mg/mL Lotion | TARGET CORPORATION | OTC MONOGRAPH DRUG |
| 11673-936 | Salicylic Acid 5 mg/mL Liquid | TARGET CORPORATION | OTC MONOGRAPH DRUG |
| 82442-060 | Phenylephrine Hydrochloride 6.25 mg/1 Suppository | Target Corporation | OTC MONOGRAPH DRUG |
| 82442-088 | Benzalkonium Chloride 130 mg/100mL Liquid | TARGET CORPORATION INC. | OTC MONOGRAPH DRUG |
Frequently asked questions
What is Up and Up used for?
Uses helps relieve the local itching and discomfort associated with hemorrhoids temporarily shrinks hemorrhoidal tissue temporarily reduces the swelling associated with irritation in hemorrhoids and other anorectal disorders
Who makes Up and Up?
Up and Up is listed by 3 labelers in the FDA NDC directory, including TARGET CORPORATION, Target Corporation, TARGET CORPORATION INC..